EVALUATION OF CYTOGENETIC AND SOMATIC EFFECTS OF CYPROHEPTADINE ON MICE
ANNIE GEORGE *
Department of Bioscience, Mangalore University, Mangalagangotri, Mangalore 574 199 D. K. Karnataka, India
M. KRISHNAMOORTHY *
Department of Bioscience, Mangalore University, Mangalagangotri, Mangalore 574 199 D. K. Karnataka, India
M. ABDUL RAHIMAN *
Department of Bioscience, Mangalore University, Mangalagangotri, Mangalore 574 199 D. K. Karnataka, India
K. K. VIJAYALAXMI *
Department of Bioscience, Mangalore University, Mangalagangotri, Mangalore 574 199 D. K. Karnataka, India
*Author to whom correspondence should be addressed.
Abstract
The genotoxic effects of cyproheptadine, the main constituent of an appetite stimulant tonic, Magnadyn was investigated in the bone marrow cells of Swiss albino mice Mus musculus. The drug was administered orally in three different doses viz., 0.1 mg/kg, 0.5 mg/kg, and 2.5 mg/kg of cyproheptadine. The therapeutic dose, 0.5 mg/kg was administered for 45 days continuously to see the effect on body weight. The mitotic metaphase stages were screened by staining in Giemsa. Statistically, non significant incidence of structural anomalies like gaps, breaks and translocations has shown that the drug is neither clastogenic nor mitoclastic. In the weight gain experiment, there was no significant increase in the body weight.
Keywords: Magnadyn, Appetite stimulant, Genotoxicity, Antihistamine