MUTAGENIC EFFECT OF SODIUM VALPORATE ON BONE MARROW CELLS OF MICE EVALUATED BY MICRONUCLEUS METHOD
K. K. VIJAYALAXMI *
Department of Biosciences, Mangalore University, Mangalagangotri-574 199, D. K. India
M. ABDUL RAHIMAN *
Department of Biosciences, Mangalore University, Mangalagangotri-574 199, D. K. India
*Author to whom correspondence should be addressed.
Abstract
The mutagenic effect of sodium valproate, an antiepileptic agent was investigated by using mouse bone marrow micronucleus test. The drug was administered intraperitoneally to experimental animals at doses of 26.66, 133.0 and 266.6 mg/kg body weight. Bone marrow micronucleus preparations were made at different time intervals. The drug induced statistically significant micronuclei at higher doses.