TUMORIGENESIS AND TUMOR MARKERS IN FISH: AN UPDATED REVIEW
M. TANEKHY *
Fish Diseases Department, Faculty of Veterinary Medicine, Alexandria University, Egypt.
E. E. MEHANA
Pathology Department, Faculty of Veterinary Medicine, Alexandria University, Egypt.
*Author to whom correspondence should be addressed.
Abstract
Fish is the largest class of vertebrates. Neoplasia is a known disease in fishes which is not considered to be a deadly condition for few malignancies. Cancer is the unregulated cell proliferation with the ability to invade or metastasize to other parts of the body. The tumorigenic process is marked by a competition between cellular proliferation and apoptosis characterized by genetic mutations and increased connective tissue proliferation with associated impairment of the immune system. Tumor markers are molecules produced by tumor cells or other cells of the body in response to cancer or benign conditions and thus; are of diagnostic value. Most tumor markers are secreted into blood and are assayed in blood, urine or immuno-histochemically. Diagnosis of tumors in fish is not always easy to carry out, and the tool provided by antibodies used on mammalian tissue is essential for obtaining definitive, unambiguous, and inexpensive identification. Generally, teleosts resemble other vertebrates in their predisposition to neoplastic lesions, which been widely studied, characterized, and classified. Immunohistochemistry is an extremely useful technique for the diagnosis of neoplasms. This technology relies upon antibody-based stains specific for intermediate filaments or surface markers. This review discusses the currently available tumor markers for different neoplasms in fish as well as the mostly used tumor markers in diagnosis. The objective of this review also is to provide an overview of neoplasia and the various neoplastic disease conditions in fishes as well as the most common methods used in diagnosis of fish tumors including immunohistochemistry and tumor markers.
Keywords: Fish, tumor, neoplasia, markers, tumorigenesis, diagnosis
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References
Vogelstein B, Papadopoulos N, Velculescu VE, Kinzler KW. Cancer genome landscapes. Science. 2013;339:1546-1558.
Laura E, Elizabeth E. Cell signaling in cancer. Cancer Research. 2018;Dec.17.
Sever R, Brugge J. Signal transduction in cancer. Cold Spring Harbor Perspective in Medicine. 2015;5(4):a006098-a006098.
Vegad JL. A text book of Veterinary General pathology. IBDC, Publishing Division , Khushuma complex Basement 7, Meerabai, Marg, Lucknow 226001 U.P. (India); 2007.
WHO. Cancer prevention and control in the context of an integrated approach. Global action plan for the prevention and control of NCDs. 2013-2020; 2018.
Cheng L, Wang H, Li S, Caiyan W. New insights into the mechanism of Keap1-Nrf2 interaction based on cancer-associated mutations. Life Sciences. 2021;119791:3 July.
Mayers T, Burton T, Bentz C, Ferguson J, Norman S. Disease of wild and cultured fishes in Alska USA. Fish pathology Laboratories and Alska Department of fish and Games.USA; 2019.
Barbara DP, Ruth F. Neoplasia of fish. MSD Manual: Veterinary Manual. University of Florida; 2015.
Fred P. Tumor prevalance and biomarkers of exposure and response in Brown Bullhead .US Fish and Wildlife service .Chesapeake Bay field office. Annapolis. 2003;1-4.
Masahito P, Ishikawa T, Sugano H. Pigment cells and pigment cell tumors in fish. J. Invest. Dermatol. 1989;92(5):2665-2705.
Joseph MG. Neoplasia in fishes. Vet. Clin. North Am. Exot. Anim. Pract. 2004;7(3):705-756.
Sonia M, Jerry H, Charlie S, Vicki B. Fish histology and histopathology. Fish neoplasia. USFWS-NCTC. 2007;6-45.
Lionel E, Thomas M. Neoplasia in fish. A review. Current Topics in Comparative Pathobiology. 1971;1:87-170.
PETMD. Tumors and cancers in fish. PetMD. s Newsletter. 2008;1-4.
Ribelin WE, Migaki G. The pathology of fishes: proceedings of a symposium. University of Wisconsin Press, Madison; 1975.
Groff JM. Neoplasia in fishes. Veterinary Clinics of North America: Exotic Animal Practice. 2004;7:705– 756.
Vergneau-Grosset C, Nadeau ME, Groff JM. Fish oncology: diseases, diagnostics, and therapeutics. Veterinary Clinics: Exotic Animal Practice. 2017;20:21– 56.
Kannan V, Vasudevan DM. Organic specific markers : What's new? Indian J. Clin.Biochem. 2012;27(2):110- 120 .
Jacques R. Comparative study of tumorigenesis and tumor immunity in vertebrates and non-mammalian vertebrates. Dev. Comp. Immunol. 2010;34(9):915-25.
Iaria C, Ieni A, Corti I, Puleio R. Immunohistochemical study of four fish tumors. J. Aquatic Animal Health. 2019;31:97-106.
Dabbs DJ. Diagnostic immunohistochemistry: theranostic and genomic applications. Elsevier/Saunders, Philadelphia; 2010.
Paquette CE, Kent ML, Peterson TS, Wang R, Dashwood RH, Löhr CV. Immunohistochemical characterization of intestinal neoplasia in Zebrafish (Danio rerio) indicates epithelial origin. Diseases of Aquatic Organisms. 2015;116:191– 197.
Nair RR, Johnson JK. A dictionary to tumor markers and the methods of estimation. Advanced Biotech. 2008;22–32.
Malati T. Tumour markers: an overview. Ind J Clin Biochem. 2007;22(2):17–31.
Ishii M. Limitations of clinical usefulness of tumor marker. Gan To Kagaku Ryoho. 1995;22(9):1139–1145.
Lanteri G, Ieni A, Toffan A, Abbate J, Saraò M, Barresi V, Macrì B. Immunohistochemical patterns of a non-viral papilloma in Goldfish (Carassius auratus, L.). Bulletin of the European Association of Fish Pathologists. 2016;36:208– 213.
Kidd ME, Shumaker DK, Ridge KM. The role of vimentin intermediate filaments in the progression of lung cancer. American Journal of Respiratory Cell and Molecular Biology. 2014;50:1– 6.
Bunton TE. Expression of actin and desmin in experimentally induced hepatic lesions and neoplasms from Medaka (Oryzias latipes). Carcinogenesis. 1995;16:1059–1063.
Romano LA, Tabata YA, Alexandrino A. Histopathological and immunohistochemical diagnostic of carcinosarcoma of mandible in a Rainbow Trout (Oncorhynchus mykiss). Acta Scientiae Veterinariae. 2010;38:319– 322.
Marino F, Germanà A, Panebianco A. A case of schwannoma in farmed Seabream Sparus aurata. Diseases of Aquatic Organisms. 2008;82:249– 252.
Germanà A, Marino F, Guerrera MC, Campo S, de Girolamo P, Montalbano G, Germanà GP, Ochoa-Erena FJ, Ciriaco E, Vega JA. Expression and distribution of S100 protein in the nervous system of the adult Zebrafish (Danio rerio). Microscopy Research and Technique. 2008;71: 248– 255.
Pitcovski J, Shahar E, Aizenshtein E, Gorodetsky R. Melanoma antigens and related immunological markers. Critical Reviews in Oncology/Hematology. 2017;115:36– 49.
Fine SW, McClain SA, Li M. Immunohistochemical staining for calretinin is useful for differentiating schwannomas from neurofibromas. American Journal of Clinical Pathology. 2004;122:552– 559.
Patton EE, Mathers ME, Schartl M. Generating and analyzing fish models of melanoma. Pages 339– 366 in H. W. Detrich, M. Westerfield, and L. I. Zon, editors. The Zebrafish: disease models and chemical screens. Academic Press, Waltham, Massachusetts; 2011.
Ibrahim AD. Immunoassay methods and their applications in pharmaceutical analysis: basic methodology and recent advances. Int J Biomed Sci. 2(3): 217–235.
Ramos-Vara JA, Miller MA (January 2014). When tissue antigens and antibodies get along: revisiting the technical aspects of Immunohistochemistry--the red, brown, and blue technique. Veterinary Pathology. 2006;51(1):42–87.
Wangsa D, Haddad KH, Ried P, Lundqvist EA. Fluorescence in Situ hybridization markers of cervical lymph node metastasis. Am. J. Pathol. 2009;17(6):2637-2645.
Gerber F, Krummen M, Potgeter H, Roth A, Siffrin C, Spoendlin C. "Practical aspects of fast reversed-phase high-performance liquid chromatography using 3μm particle packed columns and monolithic columns in pharmaceutical development and production working under current good manufacturing practice. Journal of Chromatography A. 2004;1036(2):127–133.
Duncan TE, Harkin JC. Electron microscopic studies of Goldfish tumors previously termed neurofibromas and schwannomas. American Journal of Pathology. 1969;55: 191– 202.
Schmale MC, Gibbs PDL, Campbell CE. A virus-like agent associated with neurofibromatosis in damselfish. Diseases of Aquatic Organisms. 2002;49:107– 115.
Maugeri-Saccà M, Maria R. Translating basic research in cancer patient care. Ann Ist Super Sanita. 2011;47(1):64–71.
Yanez JM, Joshi R, Yoshida GM. Genomics to accelerate genetic improvement in tilapia. Anim. Genet. 2020;51(5):658-674.
FAO. Fisheries and aquaculture software. Fish Stat J—software for fishery statistical time series. Rome, Italy: FAO Fisheries and Aquaculture. Department; 2014.
Samy-Kamal M. Status of fisheries in Egypt: Reflections on past trends and management challenges. Reviews in Fish Biology and Fisheries. 2015;25(4):631– 649.
Soliman NF, Yacout DM. Aquaculture in Egypt: Status, constraints and potentials. Aquaculture International. 2016;24(5):1201– 1227.
Shengyan SU, Dong Z. Comparative expression analysis of bone morphogenetic protein (BMP4) expressions in muscles of tilapia and common carp indicate that BMP4 plays a role in the intermuscular bone distribuation in a dose-dependent manner .Gene Expr. Patterns. 2018;27:106-113.
AFIP. Tumors of the thyroid and Parathyroid glands. Atlas of tumor pathology. Series 4 By Juan Rosai; 2015.
Kyuseok IM, Sergey M, Palma MF, Yong WH. An introduction to performing immunofluorescence staining. Methods Mol. 2019;1897: 299-311.