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The present study was conducted to evaluate blood biochemical profile of local rabbits in Tiaret region and to assess the pregnancy influence on minerals serum of local rabbits raised in semi-arid climate type. Fifty-nine multiparous does was used in this study during 2019. The semi-intensive rhythm of reproduction was used. All pregnant does were at the late stage of pregnancy at the sampling date, blood samples were collected from pregnant and non–pregnant does, serum samples were collected in two seasons: Winter and summer. In this study, biochemical parameters concentrations of pregnant rabbits were significantly higher (p<0,05) compared with non-pregnant rabbit. The value of biochemical parameters total protein, albumin, triglyceride, cholesterol, calcium and phosphorus changed significantly. In this study the potassium mean value for all does was 5,35±1,25 mmol/l, a significant (p<0,05) difference was recorded between pregnant and non-pregnant does. The mean value in pregnant does was significantly higher (p<0,05) with 5,71±1,24 mmol/l against 4,93±1,14 mmol/l in non-pregnant ones. In this study, most parameters were influenced by pregnancy, which causes deterioration in some biochemical parameters. It can be concluded that result might be useful for health and production studies of the locale population and may avoid reproduction problems.
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