J. B. S. HALDANE AS A PIONEER OF MODERN HUMAN GENETICS
F. VOGEL *
Institute of Human Genetics, University of Heidelberg, Germany
*Author to whom correspondence should be addressed.
Abstract
J. B. S. Haldane (1892-1964) was a scientist with widespread interest in physiology, biochemistry and genetics. And he was one of the founding fathers of modern human genetics. Three aspects of his work will mainly be discussed:
1) He was the first to estimate human mutation rates.
2) Much of his work was centered around natural selection. Among other basic concepts, be brought forward the hypotehsis that the genetic constitution of present-day human populations has been shaped by selective advantages and disadvantages in relation to infectious diseases of the past.
3) He contributed significantly to development of methods for establishing linkage in man. He was a great friend of India, spent the last years of his life in this country, learned from Indian culture, and was a teacher of many Indian Scientists.
Keywords: J. B. S. Haldane, Selection and Mutation, Human Genetics