UNSCHEDULED DNA SYNTHESIS IN MOUSE GASTRIC MUCOSA TREATED WITH BETEL INGREDIENTS

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Published: 1988-02-01

Page: 79-83


SOUMITRA SEN *

Human Genetics Unit, Centre for Advanced Study in cell and Chromosome Research, University of Calcutta, Department of Botany, 35 Ballygunj Circular Road, Calcutta 700019, India

GEETA TALUKDER *

Human Genetics Unit, Centre for Advanced Study in cell and Chromosome Research, University of Calcutta, Department of Botany, 35 Ballygunj Circular Road, Calcutta 700019, India

ARCHANA SHARMA *

Human Genetics Unit, Centre for Advanced Study in cell and Chromosome Research, University of Calcutta, Department of Botany, 35 Ballygunj Circular Road, Calcutta 700019, India

*Author to whom correspondence should be addressed.


Abstract

Induction of unscheduled DNA synthesis (UDS) in the fore stomach of inbred Swiss albino mice and C3H (Jax) mice was examined following administration of various combinations of betel quid ingredients. Effect of the quid ingredients on replicative DNA synthesis was studied to assess cytotoxicity. Betel leaf, areca nut, lime, tobacco and two popular brands of Indian chewing mixtures induced UDS to a very significant extent. While addition of betel leaf reduced the UDS, tobacco significantly increased it. Study of replicative DNA synthesis revealed that extracts of nut, nut with lime and brands of commercial flavours (pan masala) tested induced replicative DNA synthesis. The genotoxic and cytotoxic potentials of the test compounds provide quantitative risk factors especially in the light of their growing use in Asian countries


How to Cite

SEN, S., TALUKDER, G., & SHARMA, A. (1988). UNSCHEDULED DNA SYNTHESIS IN MOUSE GASTRIC MUCOSA TREATED WITH BETEL INGREDIENTS. BIONATURE, 8(2), 79–83. Retrieved from https://globalpresshub.com/index.php/BN/article/view/235

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