BIONATURE

STUDIES ON HEMOPROTEINS AND FREE RADICALS IN VIRCHOWIAN HANSENIASIS AND OTHER BODY DISODERS

RAVINDRA KUMAR *

Medical Physics Research Laboratory, Department of Physics & Astrophysics, University of Delhi, Delhi -110 007, India

M. M. BAJAJ *

Medical Physics Research Laboratory, Department of Physics & Astrophysics, University of Delhi, Delhi -110 007, India

BINAY SWAROOP *

Medical Physics Research Laboratory, Department of Physics & Astrophysics, University of Delhi, Delhi -110 007, India

*Author to whom correspondence should be addressed.

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Abstract

Hyperfine structure parameters of hemoproteins in four different body disorders are examined using the electron paramagnetic resonance technique at 77 K and 303 K. g value increases in all types of disorders (i.e. lepromatous leprosy, LL; pulmonary tuberculosis, PTB; burns and leukemia). Spin-spin relaxation time (T₂) falls systematically in LL., PTB, burns and leukemia. The value of line width ∆H_1/2, is found to highly susceptible in M. leprae infection.

One of the major contribution of the present work is to establish that Fe²⁺transition metal ions are in low concentration and Cu²⁺ metal ions are in high concentration in LL hemoprotein samples as compared to normals.

Keywords: Biophysical techniques, Hemoproteins in body disorders, Paramagnetic resonance technique in leprosy

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