Effect of Cerivastatin on Permeability of Lipid-raft-mimetic Membranes


Published: 2023-09-18

DOI: 10.56557/bn/2023/v43i21861

Page: 1-5

Jin-Won Park *

Department of Chemical and Biomolecular Engineering, College of Energy and Biotechnology, Seoul National University of Science and Technology, 232 Gongneung-ro, Nowon-gu, Seoul, 01811, Republic of Korea.

*Author to whom correspondence should be addressed.


The effect of cerivastatin (CER) on the permeability of lipid-raft-mimetic membrane was investigated. CER is a drug candidate to treat dyslipidemia and cardiovascular diseases. Sphingomyelin (SM) was used to form the outer layer of liposomes of which inner layer was prepared with dioleoylphosphatidic-acid. The permeability of the SM layer was estimated by measuring the release of the pyranine encapsulated in the liposome. The change of the permeability was analyzed with the presence of CER dispersion in PBS buffer, especially its hydrophobic group. The results of this study seem to be useful in deriving the drug candidate for cardiovascular disease.

Keywords: Cerivastatin, permeability, lipid raft, sphingomyelin, liposome

How to Cite

Park , J.-W. (2023). Effect of Cerivastatin on Permeability of Lipid-raft-mimetic Membranes. BIONATURE, 43(2), 1–5. https://doi.org/10.56557/bn/2023/v43i21861


Download data is not yet available.


Park Y, Park JW. Specific detection of pe-included vesicles using cyclic voltammetry. Appl. Sci. 2021;11:3660. Available:https://doi.org/10.3390/app11083660.

Wang HY, Bharti D, Levental I. Membrane heterogeneity beyond the plasma membrane. Front. Cell Dev. Biol. 2020;8:580814. Available:https://doi.org/10.3389/fcell.2020.580814.

Lingwood D, Simons K. Lipid rafts as a membrane-organizing principle. Science 2010;327:46-50. Available:https://doi.org/10.1126/science.1174621.

Corsini A. The safety of hmg-coa reductase inhibitors in special populations at high cardiovascular risk. Cardivasc. Drugs Ther. 2003;17:265–285. Available:https://doi.org/10.1023/a:1026132412074.

Istvan ES, Deisenhofer J. Structural mechanism for statin inhibition of HMG-CoA reductase. Science. 2001;292:1160-1164. Available:https://doi.org/10.1126/science.1059344.

Zaborowska M, Broniatowski M, Fontaine P, Bilewicz R, Matyszewsk D. Statin action targets lipid rafts of cell membranes: GIXD/PM-IRRAS investigation of langmuir monolayers. J. Phys. Chem. B 2023;127:7135-7147. Available:https://doi.org/10.1021/acs.jpcb.3c02574

Sinnett-Smith J, Torres-Marquez ME, Chang JK, Shimizu Y, Hao F, Martin MG, Rozengurt E. Statins inhibit protein kinase D (PKD) activation in intestinal cells and prevent PKD1-induced growth of murine enteroids. Am. J. Physiol. Cell Physiol. 2023;324:C807-C820. Available:https://doi.org/10.1152/ajpcell.00286.2022.

Kim SH, Park Y, Matalon S, Franses EI. Effect of buffer composition and preparation protocol on the dispersion stability and interfacial behavior of aqueous DPPC dispersions. Colloids Surf. B: Biointerfaces 2008;67:253-260. Available:https://doi.org/10.1016/j.colsurfb.2008.09.003.

Adams EM, Casper CB, Allen HC. Cation enrichment on dipalmitoylphosphatidylcholine (DPPC) monolayers at air-water interface. J. Colloid Interface Sci. 2016;478: 353-364.


Galiullina LF, Musabirova GS, Latfullin IA, Aganov AV, Klochkov VV. Spatial structure of atorvastatin and its complex with model membrane in solution studied by Nmr and theoretical calculations. J. Mol. Struct. 2018;1167:69-77. Available:https://doi.org/10.1016/j.molstruc.2018.04.012.

Galiullina LF, Aganova OV, Latfullin IA, Musabirova GS, Aganov AV, Klochkov VV. Interaction of different statins with model membranes by NMR data. Biochim. Biophys. Acta – Biomembr. 2017;1859: 295-300. Available:https://doi.org/10.1016/j.bbamem.2016.12.006.

Park JW. Phase asymmetry effect on vesicle fusion induced by phospholipase D. Korean Chem. Eng. Res. 2015;53:672-676. Available:http://dx.doi.org/10.9713/kcer.2015.53.6.672.

Park JW. Effect of trehalose on biological membranes with respect to phase of the membranes. KSBB J. 2017;32:103-107. Available:http://dx.doi.org/10.7841/ksbbj.2017.32.2.103.

New RRC. Liposomes: A practical approach. Academic Press, New York, USA. 1990;20-41.