Amplification of Amyloid Beta Fibril Detection Based on Mediator-Encapsulated Liposomes

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Published: 2023-11-08

Page: 20-25


Jin-Won Park *

Department of Chemical and Biomolecular Engineering, College of Energy and Biotechnology, Seoul National University of Science and Technology, 232 Gongneung-ro, Nowon-gu, Seoul, 01811, Republic of Korea.

*Author to whom correspondence should be addressed.


Abstract

Aim: Amplifying the detection of amyloid beta peptide (Aβ peptide)

Methodology: Release of ferricyanide out of the liposomes, which was induced by the interaction between the liposomes and the peptides

Findings: Detection limit was 5 pg/mL, and the linear range was 0.01 to 10 ng/mL.

Conclusion: Sensitivity of this detection was almost identical with the comparable technique such as the bioassay based on gold nanostructures.

Recommendation: Methodology developed in this study was feasible as the portable and ultrasensitive method.

Keywords: Amyloid beta peptide, ph-sensitive liposomes, encapsulating ferricyanide, cyclic voltammetry


How to Cite

Park , J.-W. (2023). Amplification of Amyloid Beta Fibril Detection Based on Mediator-Encapsulated Liposomes. Asian Journal of Research in Medicine and Medical Science, 5(1), 20–25. Retrieved from https://globalpresshub.com/index.php/AJRMMS/article/view/1892

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