Molecular Mechanism of Long Non-Coding RNAs that Involves on Regulation of the Immune System and Gene Expression

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Published: 2024-01-15

Page: 1-16

Temesgen Mitiku *

Department of Medical Biotechnology, Dambi Dollo University, Dambi dollo, Ethiopia.

Betelhem Abebe

Department of Biotechnology University of Gondar, Gondar, Ethiopia.

*Author to whom correspondence should be addressed.


Even though RNAs are often seen as connectors between DNA and proteins, transcriptome analysis reveals that only a small portion of the genome is responsible for coding proteins, while the majority is responsible for noncoding RNAs (ncRNAs). Over the past decade, ncRNAs have become increasingly fascinating due to their involvement in various physiological processes. Furthermore, their malfunctioning can have significant implications for several pathologies, including viral infections and antiviral responses. LncRNAs, which are RNA molecules larger than 200 bp, are unable to produce proteins. Numerous studies have shown that lncRNAs play a crucial role in immune and transcription regulation. Specifically, these lncRNAs have the potential to influence innate and adaptive immune responses, impacting immune system regulation at different levels of gene expression through various physiologically relevant interactions such as RNA-DNA, RNA-protein, and RNA-DNA interactions. LncRNAs are found in various immune cells, including monocytes, macrophages, dendritic cells, neutrophils, T cells, and B cells. Although they have been shown to be involved in a range of natural processes, such as gene expression regulation, dosage compensation, and genomic imprinting, there is still limited understanding of how lncRNAs are controlled and how they contribute to cell differentiation and function. This review aims to provide an overview of the functional advancements and action mechanisms of lncRNAs in immune regulation and gene expression, specifically focusing on the molecular mechanisms involved.

Keywords: Gene expression, immune cell, interaction, long non-coding ribose nucleic acid

How to Cite

Mitiku, T., & Abebe, B. (2024). Molecular Mechanism of Long Non-Coding RNAs that Involves on Regulation of the Immune System and Gene Expression. Asian Journal of Research in Biosciences, 6(1), 1–16. Retrieved from


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