Genomic and Proteomic: Their Tools and Application


Published: 2022-01-21

Page: 48-61

Susrita Sharma

SOA University, Odisha, India.

B. Ray *

GCP, SBP, Odisha, India.

S. K. Mahapatra

IPT, Salipur, Odisha, India.

*Author to whom correspondence should be addressed.


Genomics is an Interdisciplinary branch of Applied Biology which deals with the structure, Function, Evolution, mapping and editing of genomes. Proteomics is the large-scale study of proteins. Proteins are vital parts of living organisms, with many functions. The proteome is the entire set of proteins produced or modified by an organism or system. Proteomics enables the identification of ever-increasing numbers of proteins. The Present Review Focus the Different  Event and aspects of Genomics and Proteomics.

Keywords: Genomics, proteomics, genome, sequencing, protein

How to Cite

Sharma, S., Ray, B., & Mahapatra, S. K. (2022). Genomic and Proteomic: Their Tools and Application. Asian Journal of Research in Biosciences, 4(1), 48–61. Retrieved from


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Jump up to:a b c d e f Weston, Andrea D, Hood Leroy. Systems biology, proteomics, and the future of health care: toward predictive, preventative, and personalized medicine. Journal of Proteome Research. 2004;3 (2):179–96.

CiteSeerX doi:10.1021/pr0499693. PMID 15113093

Gupta N, Tanner S, Jaitly N, et al. Whole proteome analysis of post-translational modifications: Applications of mass-spectrometry for proteogenomic annotation. Genome Res. 2007;17 (9): 1362-77. DOI:10.1101/gr.6427907 PMC 1950905. PMID 17690205.

Gupta N, Benhamida J, Bhargava V, et al. Comparative proteogenomics: combining mass spectrometry and comparative genomics to analyze multiple genomes. Genome Res. 2008;18 (7): 1133–42. DOI:10.1101/gr.074344.107. PMC 2493402. PMID 18426904. "UniProt". "ExPASy - PROSITE".

Strimbu, Kyle; Tavel, Jorge A. What are biomarkers?. Current Opinion in HIV and AIDS. 2010;5 (6):463–6. DOI:10.1097/COH.0b013e32833ed177. PMC 3078627. PMID 20978388

Biomarkers Definitions Working Group. Biomarkers and surrogate endpoints: Preferred definitions and conceptual framework. Clinical Pharmacology & Therapeutics. 2001;69(3):89–95. DOI:10.1067/mcp.2001.113989. PMID 11240971. S2CID 288484

Ceciliani F, Eckersall D, Burchmore R, Lecchi C. Proteomics in veterinary medicine: applications and trends in disease pathogenesis and diagnostics (PDF). Veterinary Pathology. 2014;51 (2):351–362. DOI:10.1177/0300985813502819. hdl:2434/226049. PMID 24045891. S2CID 25693263

Visser NF, Heck AJ. Surface plasmon resonance mass spectrometry in proteomics. Expert Review of Proteomics. 2008;5 (3):425–33. DOI:10.1586/14789450.5.3.425. PMID 18532910. S2CID 11772983

Jump up to:a b Bensimon, Ariel; Heck, Albert JR, Aebersold, Ruedi. Mass spectrometry–based proteomics and network biology. Annual Review of Biochemistry. 2012;81(1):379–405. DOI: 10.1146/annurev-biochem-072909-100424. PMID 22439968

Jump up to:a b Sabidó, Eduard; Selevsek, Nathalie; Aebersold, Ruedi. "Mass spectrometry-based proteomics for systems biology". Current Opinion in Biotechnology. 2012;23(4):591–597. DOI:10.1016/j.copbio.2011.11.014. PMID 22169889

Jump up to:a b "What is Proteomics?". ProteoConsult.[unreliable medical source?]

Klopfleisch R, Gruber AD, Gruber. Increased expression of BRCA2 and RAD51 in lymph node metastases of canine mammary adenocarcinomas. Veterinary Pathology. 2009;46(3):416–22. DOI:10.1354/vp.08-VP-0212-K-FL. PMID 19176491. S2CID 11583190

Hathout, Yetrib. Approaches to the study of the cell secretome. Expert Review of Proteomics. 2007;4 (2):239–48. DOI:10.1586/14789450.4.2.239. PMID 17425459. S2CID 26169223.

Vaidyanathan G. Redefining clinical trials: the age of personalized medicine. Cell. 2012;148 (6):1079–80. DOI:10.1016/j.cell.2012.02.041. PMID 22424218

Wang H, Chu C, Wang W, Pai T, Chu, Wang, Pai. A local average distance descriptor for flexible protein structure comparison". BMC Bioinformatics. 2014;15(95):1471–2105. DOI:10.1186/1471-2105-15-95 PMC 3992163. PMID 24694083.

Petrov D, Margreitter C, Gandits M, Ostenbrink C, Zagrovic B, Margreitter, Grandits, Oostenbrink, Zagrovic. A systematic framework for molecular dynamics simulations of protein post-translational modifications". PLOS Computational Biology. 2013;9(7): e1003154. Bibcode:2013PLSCB...9E3154P. DOI:10.1371/journal.pcbi.1003154. PMC 3715417. PMID 23874192.

Margreitter C, Petro D, Zagrovic B; Petrov; Zagrovic. Vienna-PTM web server: a toolkit for MD simulations of portein post-translational modifications. Nucleic Acids Res. 2013;41 (Web Server issue): W422–6. DOI:10.1093/nar/gkt416. PMC 3692090. PMID 23703210.

Rakwal Randeep, Komatsu Setsuko. Role of jasmonate in the rice (Oryza sativa L.) self-defense mechanism using proteome analysis. Electrophoresis. 2000;21(12):2492–500. DOI:10.1002/1522-2683(20000701)21:12<2492::AID-ELPS2492>3.0.CO;2-2. PMID 10939463.

Wu Jianqiang, Baldwin Ian T. New insights into plant responses to the attack from insect herbivores. Annual Review of Genetics. 2010;44:1–24. DOI: 10.1146/annurev-genet-102209-163500. PMID 20649414

Sangha JS, Chen YH, Kaur Jatinder, Khan Wajahatullah, Abduljaleel Zainularifeen, Alanazi Mohammed S, Mills Aaron, Adalla Candida B, Bennett John, et al. Proteome Analysis Of Rice (Oryza Sativa L.) Mutants Reveals Differentially Induced Proteins During Brown Planthopper (Nilaparvata Lugens) Infestation. Int. J. Mol. Sci. 2013;14(2):3921–3945. DOI:10.3390/ijms14023921. PMC 3588078. PMID 23434671.

de Mol NJ. Surface plasmon resonance for proteomics. Chemical Genomics and Proteomics. Methods in Molecular Biology. 2012;800.33–53. DOI:10.1007/978-1-61779-349-3_4. ISBN 978-1-61779-348-6. PMID 21964781.

Maron JL, Alterovitz G, Ramoni M, Johnson KL, Bianchi DW; Alterovitz; Ramoni; Johnson; Bianchi. High-throughput discovery and characterization of fetal protein trafficking in the blood of pregnant women. Proteomics: Clinical Applications. 2009;3 (12):1389–96. DOI:10.1002/prca.200900109. PMC 2825712. PMID 20186258.

Swinbanks, David. Australia backs innovation, shuns telescope. Nature. 1995;378(6558): 653. Bibcode:1995Natur.378..653S. DOI:10.1038/378653a0. PMID 7501000.

*^ "APAF - The Australian Proteome Analysis Facility - APAF - The Australian Proteome Analysis Facility". Retrieved 2017-02-06.