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Hemolytic uremic syndrome (HUS) is one of the common causes of acute renal failure in children, but it is rarely encountered in newborns. It comprises of a triad of microangiopathic hemolytic anemia, non-immune thrombocytopenia and renal failure. Neonatal cases of HUS predominantly belong to the atypical category, resulting from abnormalities of the complement pathway or cobalamin C disorders. However, HUS cases due to infection have rarely been reported in newborns. For infection associated HUS e.g., due to Shiga toxin producing E.coli (STEC), presence of diarrhea is not a must and some cases associated with urinary tract infection (UTI) have also been seen. We present a case of a female newborn who developed HUS by acquiring the infection from her mother who had UTI associated HUS.
Stritt A, Tschumi S, Kottanattu L, Bucher BS, Steinmann M, von Steiger N, et al. Neonatal hemolytic uremic syndrome after mother-to-child transmission of a low-pathogenic stx2b harboring shiga toxin-producing Escherichia coli. Clin Infect Dis. 2013;56:114–6.
Ulinski T, Lervat C, Ranchin B, Gillet Y, Floret D, Cochat P. Neonatal hemolytic uremic syndrome after mother-to-child transmission of Escherichia coli O157. Pediatr Nephrol. 2005;20:1334–5.
Hogan MC, Gloor JM, Uhl JR, Cockerill FR, Milliner DS. Two cases of non-O157:H7 Escherichia coli hemolytic uremic syndrome caused by urinary tract infection. Am J Kidney Dis. 2001;38:E22.
Gerber A, Karch H, Allerberger F, Verweyen HM, Zimmerhackl LB. Clinical course and the role of shiga toxin-producing Escherichia coli infection in the hemolytic-uremic syndrome in pediatric patients, 1997–2000, in Germany and Austria: A prospective study. J Infect Dis. 2002;186:493–500.
Saikia B, Vashisht N, Gupta N, Sharma A. Exchange transfusion for neonate with haemolytic uremic syndrome. Springerplus. 2016;5:52.
Moake JL. Thrombotic microangiopathies. N Engl J Med. 2002;47:589–600.
Raina R, Krishnappa V, Blaha T, Kann T, Hein W, Burke L, et al. Atypical Hemolytic-Uremic Syndrome: An update on pathophysiology, diagnosis, and treatment: update on atypical hemolytic uremic syndrome. TherApher Dial. 2019;23:4– 21.
Morrell DS, Pepping MA, Scott JP, Esterly NB, Drolet BA. Cutaneous Manifestations of Hemophagocytic Lymphohistiocytosis. Archives of Dermatology. 2002;13:1208-12.
Banerjee S. Hemolytic uremic syndrome. Indian Pediatr. 2009;46:1075–84.