Epidermoid Carcinoma of the Lower Lip and Fanconi's Disease: A Case Report

PDF

Published: 2018-10-31

Page: 1-4


Hacene Hammoud

Department of Oral and Maxillofacial Surgery, Central Army Hospital (Doctor Mohamed Seghir Nekkache), Kouba, Algiers, Algeria.

Nora Mimoune

High National Veterinary School (HNVS), Bab-Ezzouar, Algiers, Algeria. and Laboratory of Biotechnologies Related to Animal Reproduction (LBRA), Institute of Veterinary Sciences, University Saad Dahleb, BP: 270, Soumaa Road, Blida, Algeria.

Yacine Betam

Department of Oral and Maxillofacial Surgery, Central Army Hospital (Doctor Mohamed Seghir Nekkache), Kouba, Algiers, Algeria.

Adel Guidoum

Department of Oral and Maxillofacial Surgery, Central Army Hospital (Doctor Mohamed Seghir Nekkache), Kouba, Algiers, Algeria.

Hamza Lekbir

Department of Oral and Maxillofacial Surgery, Central Army Hospital (Doctor Mohamed Seghir Nekkache), Kouba, Algiers, Algeria.

Morsli Youcef

Department of Oral and Maxillofacial Surgery, Central Army Hospital (Doctor Mohamed Seghir Nekkache), Kouba, Algiers, Algeria.

Ayoub Chahrour

Department of Oral and Maxillofacial Surgery, Central Army Hospital (Doctor Mohamed Seghir Nekkache), Kouba, Algiers, Algeria.

Wassim Belferrag

Department of Oral and Maxillofacial Surgery, Central Army Hospital (Doctor Mohamed Seghir Nekkache), Kouba, Algiers, Algeria.

Hichem Benaissa

Department of Oral and Maxillofacial Surgery, Central Army Hospital (Doctor Mohamed Seghir Nekkache), Kouba, Algiers, Algeria.

Mohamed Yassine Azzouz *

High National Veterinary School (HNVS), Bab-Ezzouar, Algiers, Algeria.

*Author to whom correspondence should be addressed.


Abstract

Fanconi's disease (FA) is a rare genetic disease with autosomal recessive transmission; which combines the classic triad, short stature, malformation syndrome, bone marrow failure. The main malformations concern the extremities, the spine, the skin, the kidneys, the urinary tract and the otolaryngological sphere. Advances in molecular biology have enabled the identification of 15 genes involved, whose mutation is responsible for hematological damage and increased neoplastic risk. Patient care is multidisciplinary, it is hematological and extra-hematological, associating screening for organ deformities and deficits with monitoring for the appearance of precancerous or tumor lesions. We report a case of a 41-year-old patient with squamous cell carcinoma of the lower lip, classified T3 N0 M0 and whose preoperative assessment awakened Fanconi's disease. The patient was operated on requiring surgical excision for carcinological purposes with immediate repair of the loss of substances (LOS).

Keywords: Fanconi's disease, lower lip, squamous cell carcinoma, cheek defect lip, refection, flap dufourmente.


How to Cite

Hammoud, H., Mimoune, N., Betam, Y., Guidoum, A., Lekbir, H., Youcef, M., Chahrour, A., Belferrag, W., Benaissa, H., & Azzouz, M. Y. (2018). Epidermoid Carcinoma of the Lower Lip and Fanconi’s Disease: A Case Report. Asian Journal of Medical Case Reports, 2(1), 1–4. Retrieved from https://globalpresshub.com/index.php/AJMCR/article/view/889

Downloads

Download data is not yet available.

References

Mridula Goswami, Urvashi Bhushan, Manoj Goswami. Dental perspective of rare disease of fanconi anemia: Case report with review. Clin Med Insights Case Rep. 2016;9:25–30.

Yang N, Chen J, Zhang H, et al. Horse versus rabbit antithymocyte globulin in immunosuppressive therapy of treatment-naive aplastic anemia: A systematic review and meta-analysis. Ann Hematol. 2017;96:2031-2043.

Stanley N, Olson TS, Babushok DV. Recent advances in understanding clonal haematopoiesis in aplastic anaemia. Br J Haematol. 2017;177:509-525.

Alter BP. Fanconi’s anemia, transplantation and cancer. Pediatr Transplant. 2005;9:81–6.

Kutler D, Singh B, Satagopan J, et al. A 20-year perspective on the International Fanconi Anemia Registry (IFAR). Blood. 2003;4:1249-1256.

Wagner JE, Tolar J, Levran O, et al. Shared genetic susceptibility to breast cancer, early onset leukemia and Fanconi anemia. Blood. 2004;103:3226-3229.

Alter BP. Cancer in Fanconi anemia, 1927–2001. Cancer. 2003;97:425-440.

Yalman N, Sepet E, Aren G, Mete Z, Kulekci G, Anak S. The effect of bone marrow transplantation on systemic and oral health in Fanconi’s aplastic anemia. J Clin Pediatr Dent. 2001;25:329–32.

Jansisyanont P, Pazoki A, Ord RA. Squamous cell carcinoma of the tongue after bone marrow transplantation in a patient with Fanconi anemia. J Oral Maxillofac Surg. 2000;58:1454–7.