Acute Disseminated Encephalomyelitis Due to Covid-19 Infection: A Case Report


Published: 2022-05-23

Page: 49-54

Enes Tarık Inci *

Department of Neurology, Ankara Training and Research Hospital, Ankara, Turkey.

Tahir Kurtuluş Yoldaş

Department of Neurology, Ankara Training and Research Hospital, Ankara, Turkey.

*Author to whom correspondence should be addressed.


Although Acute Disseminated Encephalomyelitis (ADEM) is most commonly seen in children, it can affect people of all ages. With the increasing incidence of Covid-19 infection complications, its neurological side effects have also varied. Although headache, stroke and encephalitis are the most common neurological side effects, demyelinating diseases have been reported rarely. In our case report, we present a case of ADEM due to Covid-19 infection, who presented to our clinic with visual loss in both eyes after upper respiratory tract symptoms which started 15 days ago and lasted for 3-4 days.

Keywords: Acute disseminated encephalomyelitis, COVID-19, COVID-19 infection, demyelinating disease, visual evoked potential

How to Cite

Inci, E. T., & Yoldaş, T. K. (2022). Acute Disseminated Encephalomyelitis Due to Covid-19 Infection: A Case Report. Asian Journal of Medical Case Reports, 4(1), 49–54. Retrieved from


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Yeh AE, Collins A, Cohen ME, Duffner PK, Faden H. Detection of Coronavirus in the Central Nervous System of a Child With Acute Disseminated Encephalomyelitis. PEDIATRICS. 2004;113:73-76.

Bridwell R, Long B, Gottlieb M. Neurologic complications of COVID-19. American Journal of Emergency Medicine. 2020;38:1549.e3–1549.e7.

Hochhegger B, Zanon M, Altmayer S, Mandelli NS, Stüker G, Mohammed TL, et al. Covid-19 mimics on chest CT: a pictorial review and radiologic guide Br J Radiol. 2021;94(1118): 20200703.

Tenembaum S, Chamoles N, Fejerman N. Acute disseminated encephalomyelitis: a long-term follow-up study of 84 pediatric patients. Neurology. 2002;59(8):1224-31.

Pohl D, Alper G, Van Haren K, et al. Acute disseminated encephalomyelitis: updates on an inflammatory CNS syndrome. Neurology. 2016;87:S38-S45.

Tenembaum S, Chitnis T, Ness J, Hahn JS. Acute disseminated encephalomyelitis. Neurology. 2007;68:23-36.

Schwarz S, Mohr A, Knauth M, Wildemann B, Storch–Hagenlocher B. Acute disseminated encephalomyelitis: a follow-up study of 40 adult patients. Neurology. 2001;56(10):1313-8.

Filippi M, Rocca MA. White Matter Disease: An Update for Neurologists. Milano, Italy. 2020:109-122.

Mao L, Jin H, Wang M, Hu Y, Chen S, He Q. Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan, China. JAMA Neurology. 2020;77(6):683-690.

Zelada-Ríos L, Pacheco-Barrios K , Galecio-Castillo M, Yamunaqu ́-Chunga C, Alvarez-Toledo ́K, Otiniano-Sifuentes R. Acute disseminated encephalomyelitis and COVID-19: A systematic synthesis of worldwide cases. Journal of Neuroimmunology. 2021;359:577674.

Wang Y, Wang Y, Huo L, Li Q, Chen J, Wang H. SARS-CoV-2-associated acute disseminated encephalomyelitis: a systematic review of the literature. J Neurol. 2022;269(3):1071-1092.

Helms J, Kremer S, Merdji H, Clere-Jehl R, Schenck M, Kummerlen C,et al. Neurologic features in severe SARS-CoV-2 infection. N Engl J Med. 2020;382(23):2268-70.

Waldman AT, Gorman MP, Rensel MR, Austin TE, Hertz DP, Kuntz NL. Management of pediatric central nervous system demyelinating disorders: consensus of United States neurologists. J Child Neurol. 2011;26:675–682.

Koelman DLH, Chahin S, Mar SS, et al. . Acute disseminated encephalomyelitis in 228 patients: a retrospective, multicenter US study. Neurology. 2016;86(22): 2085-2093.