Acute Motor Axonal Neuropathy Variant of Guillain Barre Syndrome: A Rare Presentation of COVID-19

Main Article Content

Mishal Haroon
Irfan Ahsan
Talha Safeer
Hira Saleem


Covid-19 has emerged as a pandemic. It originated in December 2019 in China and embraced the globe in the next few months. On January 11th, China announced the first death from this virus. We describe here one of the rare complications associated with SARS Cov 2. Among the complications reported of Covid-19, Guillain Barre syndrome has been rarely discussed. Most patients are intubated secondary to damaged lung parenchyma or Pulmonary embolism. But If respiratory failure is associated with limb weakness, then GBS should be suspected.

A 65-year-old male presented to us with loose stools, vomiting and fever for a week. On admission he was tested positive for Covid-19. He developed weakness in lower and upper extremities following one week of admission. Nerve conduction studies demonstrated the AMAN variant of GBS. IVIG or PLEX can improve outcome of such patients. Patients who cannot be weaned off should be considered for such therapies.

The novel corona virus can cause variety of symptoms in the host. It can lead to mild symptoms like dry cough, body aches, loss of smell or taste, loose stools and vomiting followed by complete recovery of the patient, or moderate to severe disease-causing shortness of breath and involvement of lung parenchyma. A spectrum of complications can eventually develop like ARDS, multiorgan dysfunction denoting critical disease. Initially it was believed that death occurred from pneumonia and its consequences. Later many patients with stroke were found to be covid positive. The correlation was found to be a thromboembolic phenomenon. Hence anticoagulation was made a part of the regimen of treatment. Now more and more studies are proving the neuro-invasive potential of this virus.

Guillain barre syndrome, neuronal loss, ACE2, EMG, NCS, IVIG

Article Details

How to Cite
Haroon, M., Ahsan, I., Safeer, T., & Saleem, H. (2021). Acute Motor Axonal Neuropathy Variant of Guillain Barre Syndrome: A Rare Presentation of COVID-19. Asian Journal of Medical Case Reports, 3(1), 89–91. Retrieved from
Case Reports


Ling Mao, Huijuan Jin, Mengdie Wang, et al. Neurological Manifestations of Hospitalized Patients with corona virus disease 2019 in Wuhan, China; JAMA Neurol. 2020;77(6):683-90.

Yesudhas D, Srivastava A, Gromiha MM. COVID-19 outbreak: history, mechanism, transmission, structural studies and therapeutics. Infection; 2020. Available:

Malik Ghannam, Qasem Alshaer, Mustafa Al-Chalabi; Neurological involvement of coronavirus disease 2019: a systemic review. J Neurol. 2020;1-19.

Soheil Mohammadi, Fatemeh Moosaie, Mohammad Hadi Aarabi. Understanding the immunological characteristics of neurological manifestations of SARS CoV 2 and potential immunological mechanisms. Mol Neurobiol. 2020;1-13.

Aaron Jesuthasan, Flavia Massey, Hadi MANJI, Michael S. Zandi, Sarah Wiethoff. Emerging potential mechanisms and predispositions to the neurological manifestations of COVID-19: J Neurol; 2021 sep 15

Kartikay Prasad, Shahzaib Ahamad, Dinesh Gupta,Vijay Kumar: Targeting cathepsins: A potential link between COVID-19 and associated neurological manifestations: Heliyon; 2021.