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Zika virus is an emerging mosquito-borne flavivirus. Dengu and malaria are important mosquito -borne viral disease. Globally, dengu is the most common mosquito-borne viral disease, 390 million infections per year and 40% of the world's population at risk. Zika virus is transmitted by Ae, aegypti mosquitoes and originated from Africa and Asia. Zika virus is a single stranded RNA virus of 11000-nucleotide. Zika virus was first found in 1947 from a rhesus monkey. Zika virus is an arthropod borne virus (arbovirus). Zika virus was first isolated from 1947. A virus can be transmitted by one from another by bite. Zika virus is globally spread disease. Zika virus is transmitted or spread by Aedes mosquitoes. Zika virus belongs to the family flavivirus. Not only, spread by Aedes mosquito but also spread by sexual transmission, blood transfusion etc. Zika virus causes a neurological disease in humans.