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A brief account of poisonous plants of Bilaspur district, Chattisgarh has been presented in this paper. A total 40 poisonous plant species belonging to 32 genera and 20 families have been described. This is also briefly emphasized that plants contain numerous chemical compounds which are poisionous when misused and the same plants also yield compounds which are used for preparing life saving drugs. Typical examples are Gloriosa superba and Catharanthus roseus (Vinca rosea) and many more. All poisonous plants enumerated here are arranged alphabetically on their scientific name followed by family’s, local name, poisonous part and toxic compound (s) therein.